氧化铱/聚多巴胺/层粘连蛋白仿生涂层的制备

Preparation of Iridium Oxide/Polydopamine/Laminin Biomimetic Layer

中文关键词: 氧化铱 多巴胺 仿生涂层 生物相容性

英文关键词: iridium oxide, dopamine, biomimetic layer, biocompatibility

中文摘要:

      神经电极的生物相容性是制约植入式神经假体长期使用功效的核心要素,对电极表面进行修饰改性可有效提高电极活性。本研究利用射频磁控溅射和循环伏安法在钛基体表面形成氧化铱薄膜,通过多巴胺氧化自聚合修饰氧化铱薄膜,进一步在涂层表面接枝层粘连蛋白实现二次功能化,完成仿生涂层的构建。对涂层的理化性质研究表明,其机械稳定性较好,表面亲水性以及电化学性能得到显著提高,并且无细胞毒性,促细胞粘附能力较好。

英文摘要:

      The biocompatibility of electrode-tissue interface is a crucial factor that influences the long-term performances of neural prosthesis. The modification of the electrode surface can significantly improve the biocompatibility at the implant site. Iridium oxide films were formed on the surface of titanium substrate by RF magnetron sputtering and cyclic voltammetry. Modified by dopamine and laminin, the iridium oxide/polydopamine/laminin biomimetic layer was prepared. The physical and chemical characterizations of the biomimetic layer show that the electrochemical properties and hydrophilicity are significantly improved. The layer is stable, without cytotoxicity. Besides, the layer promotes cell adhesion of PC12.